PT  - JOURNAL ARTICLE
AU  - Donald E. Mager
AU  - Elzbieta Wyska
AU  - William J. Jusko
TI  - Diversity of Mechanism-Based Pharmacodynamic Models
AID  - 10.1124/dmd.31.5.510
DP  - 2003 May 01
TA  - Drug Metabolism and Disposition
PG  - 510--518
VI  - 31
IP  - 5
4099  - http://dmd.aspetjournals.org/content/31/5/510.short
4100  - http://dmd.aspetjournals.org/content/31/5/510.full
SO  - Drug Metab Dispos2003 May 01; 31
AB  - Pharmacodynamics is the study of the time course of pharmacological effects of drugs. The field of pharmacodynamic modeling has made many advances, due in part to the relatively recent development of basic and extended mechanism-based models. The purpose of this article is to describe the classic as well as contemporary approaches, with an emphasis on pertinent equations and salient model features. In addition, current methods of integrating various system complexities into these models are discussed. Future pharmacodynamic models will most likely reflect an assembly of the basic components outlined in this review. The American Society for Pharmacology and Experimental Therapeutics