PT - JOURNAL ARTICLE AU - Peter G. Wells AU - Peter I. Mackenzie AU - Jayanta Roy Chowdhury AU - Chantal Guillemette AU - Philip A. Gregory AU - Yuji Ishii AU - Antony J. Hansen AU - Fay K. Kessler AU - Perry M. Kim AU - Namita Roy Chowdhury AU - Joseph K. Ritter TI - GLUCURONIDATION AND THE UDP-GLUCURONOSYLTRANSFERASES IN HEALTH AND DISEASE AID - 10.1124/dmd.32.3.281 DP - 2004 Mar 01 TA - Drug Metabolism and Disposition PG - 281--290 VI - 32 IP - 3 4099 - http://dmd.aspetjournals.org/content/32/3/281.short 4100 - http://dmd.aspetjournals.org/content/32/3/281.full SO - Drug Metab Dispos2004 Mar 01; 32 AB - This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies. The American Society for Pharmacology and Experimental Therapeutics