RT Journal Article
SR Electronic
T1 EPOXIDE METABOLITES OF PROTRIPTYLINE IN RAT URINE
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 80
OP 84
VO 3
IS 2
A1 H. B. HUCKER
A1 A. J. BALLETTO
A1 J. DEMETRIADES
A1 B. H. ARISON
A1 A. G. ZACCHEI
YR 1975
UL http://dmd.aspetjournals.org/content/3/2/80.abstract
AB Two epoxide metabolites of 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene (protriptyline) were identified in the urine of rats given 14C-labeled drug. They were characterized by mass spectrometry, nuclear magnetic resonance spectrometry, and chemical reactivity as 10,11-dihydro-10,11-epoxy-5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene (I) and 10,11-dihydro-10,11-epoxy-5(3-aminopropyl)-5H-dibenzo[a,d]cycloheptene (II). Over twice as much I as II was excreted and together the two metabolites accounted for approximately 40% of the urinary radioactivity. Copyright © 1975 by The American Society for Pharmacology and Experimental Therapeutics