PT  - JOURNAL ARTICLE
AU  - Gradolatto, Angéline
AU  - Basly, Jean-Philippe
AU  - Berges, Raymond
AU  - Teyssier, Caroline
AU  - Chagnon, Marie-Christine
AU  - Siess, Marie-Héléne
AU  - Canivenc-Lavier, Marie-Chantal
TI  - PHARMACOKINETICS AND METABOLISM OF APIGENIN IN FEMALE AND MALE RATS AFTER A SINGLE ORAL ADMINISTRATION
AID  - 10.1124/dmd.104.000893
DP  - 2005 Jan 01
TA  - Drug Metabolism and Disposition
PG  - 49--54
VI  - 33
IP  - 1
4099  - http://dmd.aspetjournals.org/content/33/1/49.short
4100  - http://dmd.aspetjournals.org/content/33/1/49.full
SO  - Drug Metab Dispos2005 Jan 01; 33
AB  - The metabolism of apigenin, a weak estrogenic flavonoid phytochemical, was investigated in the rat. After a single oral administration of radiolabeled apigenin, 51.0% of radioactivity was recovered in urine, 12.0% in feces, 1.2% in the blood, 0.4% in the kidneys, 9.4% in the intestine, 1.2% in the liver, and 24.8% in the rest of the body within 10 days. Sex differences appear with regard to the nature of compounds eliminated via the urinary route: immature male and female rats, like mature female rats, excreted a higher percentage of the mono-glucuronoconjugate of apigenin than the mono-sulfoconjugate of apigenin (10.0-31.6% versus 2.0-3.6%, respectively). Mature male rats excreted the same compounds in an inverse ratio (4.9% and 13.9%, respectively). Radioactivity appeared in the blood only 24 h after oral administration. Blood kinetics showed a high elimination half-time (91.8 h), a distribution volume of 259 ml, and a plasmatic clearance of 1.95 ml/h. All of the parameters calculated from these experiments suggested a slow metabolism of apigenin, with a slow absorption and a slow elimination phase. Thus, a possible accumulation of this flavonoid in the body can be hypothesized. The American Society for Pharmacology and Experimental Therapeutics