PT  - JOURNAL ARTICLE
AU  - C. C. PORTER
AU  - B. H. ARISON
AU  - V. F. GRUBER
AU  - D. C. TITUS
AU  - W. J. A. VANDENHEUVEL
TI  - HUMAN METABOLISM OF CYPROHEPTADINE
DP  - 1975 May 01
TA  - Drug Metabolism and Disposition
PG  - 189--197
VI  - 3
IP  - 3
4099  - http://dmd.aspetjournals.org/content/3/3/189.short
4100  - http://dmd.aspetjournals.org/content/3/3/189.full
SO  - Drug Metab Dispos1975 May 01; 3
AB  - Gas-liquid chromatographic and mass. nuclear magnetic resonance. and infrared spectrometric techniques were utilized to identify some of the metabolites of cyproheptadine in the urine of human subjects who had ingested radiolabeled drug. Aromatic ring hydroxylation ( followed by glucuronide conjugation). N-demethylation. end heterocyclic ring oxidation were shown to occur in man. The principal metabolite. however. was identified tentatively as a quaternary ammonium. glucuronide-like conjugate of cyproheptadine. No evidence was found for metabolic changes at the tricyclic ethylene bridge in this species. Copyright © 1975 by The American Society for Pharmacology and Experimental Therapeutics