PT  - JOURNAL ARTICLE
AU  - L. P. Jordheim
AU  - T. Nguyen-Dumont
AU  - X. Thomas
AU  - C. Dumontet
AU  - S. V. Tavtigian
TI  - Differential Allelic Expression in Leukoblast from Patients with Acute Myeloid Leukemia Suggests Genetic Regulation of <em>CDA</em>, <em>DCK</em>, <em>NT5C2</em>, <em>NT5C3</em>, and <em>TP53</em>
AID  - 10.1124/dmd.108.023184
DP  - 2008 Dec 01
TA  - Drug Metabolism and Disposition
PG  - 2419--2423
VI  - 36
IP  - 12
4099  - http://dmd.aspetjournals.org/content/36/12/2419.short
4100  - http://dmd.aspetjournals.org/content/36/12/2419.full
SO  - Drug Metab Dispos2008 Dec 01; 36
AB  - mRNA expression levels of certain genes have shown predictive value for the outcome of cytarabine-treated AML-patients. We hypothesized that genetic variants play a role in the regulation of the transcription of these genes. We studied leukoblasts from 82 patients with acute myeloid leukemia and observed various extent and frequency of differential allelic expression in the CDA, DCK, NT5C2, NT5C3, and TP53 genes. Our attempts to identify the causative regulatory single nucleotide polymorphisms by a bioinformatics approach did not succeed. However, our results indicate that genetic variations are at least in part responsible for the differences in overall expression levels of these genes. The American Society for Pharmacology and Experimental Therapeutics