TY - JOUR T1 - IDENTIFICATION AND URINARY EXCRETION OF <em>p</em>-CHLOROPHENOXYACETAMIDE, A METABOLITE OF IPROCLOZIDE, IN HUMANS JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 423 LP - 429 VL - 3 IS - 6 AU - R. M. DE SAGHER AU - A. P. DE LEENHEER AU - A. A. CRUYL AU - A. E. CLAEYS Y1 - 1975/11/01 UR - http://dmd.aspetjournals.org/content/3/6/423.abstract N2 - The presence of p-chlorophenoxyacetamide was detected in the urine of man receiving iproclozide [1-(p-chlorophenoxyacetyl)-2-isopropylhydrazine]. This new metabolite was identified by combined gas-liquid chromatography-mass spectrometry and by comparison with the synthetic compound. An appropriate procedure for the extraction and quantitation of p-chlorophenoxyacetamide by gas-liquid chromatography on a 5% OV-225-packed column with the 2-butyl analog of iproclozide as an internal standard, has been developed. After 20- and 50-mg single dose oral administrations of iproclozide, 5.2 and 8.3% were slowly excreted in urine as p-chlorophenoxyacetamide within 30.5 and 36 hr, respectively. After 20-mg oral intakes by psychiatric patients, the 24-hr urinary excretion of p-chlorophenoxyacetamide amounted to about 2-4% of the iproclozide dose administered. Copyright © 1975 by The American Society for Pharmacology and Experimental Therapeutics ER -