RT Journal Article SR Electronic T1 IDENTIFICATION AND URINARY EXCRETION OF p-CHLOROPHENOXYACETAMIDE, A METABOLITE OF IPROCLOZIDE, IN HUMANS JF Drug Metabolism and Disposition JO Drug Metab Dispos FD American Society for Pharmacology and Experimental Therapeutics SP 423 OP 429 VO 3 IS 6 A1 R. M. DE SAGHER A1 A. P. DE LEENHEER A1 A. A. CRUYL A1 A. E. CLAEYS YR 1975 UL http://dmd.aspetjournals.org/content/3/6/423.abstract AB The presence of p-chlorophenoxyacetamide was detected in the urine of man receiving iproclozide [1-(p-chlorophenoxyacetyl)-2-isopropylhydrazine]. This new metabolite was identified by combined gas-liquid chromatography-mass spectrometry and by comparison with the synthetic compound. An appropriate procedure for the extraction and quantitation of p-chlorophenoxyacetamide by gas-liquid chromatography on a 5% OV-225-packed column with the 2-butyl analog of iproclozide as an internal standard, has been developed. After 20- and 50-mg single dose oral administrations of iproclozide, 5.2 and 8.3% were slowly excreted in urine as p-chlorophenoxyacetamide within 30.5 and 36 hr, respectively. After 20-mg oral intakes by psychiatric patients, the 24-hr urinary excretion of p-chlorophenoxyacetamide amounted to about 2-4% of the iproclozide dose administered. Copyright © 1975 by The American Society for Pharmacology and Experimental Therapeutics