TY - JOUR T1 - EFFECT OF 3-METHYLCHOLANTHRENE TREATMENT ON PHENACETIN O-DEALKYLATION IN SEVERAL INBRED MOUSE STRAINS JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 502 LP - 506 VL - 3 IS - 6 AU - P. J. POPPERS AU - W. LEVIN AU - A. H. CONNEY Y1 - 1975/11/01 UR - http://dmd.aspetjournals.org/content/3/6/502.abstract N2 - An increase in the metabolism of phenacetin to N-acetyl-p-aminophenol is correlated with benzo[a]pyrene hydroxylase induction by 3-methylcholanthrene among several inbred mouse strains. While the magnitude of induction of phenacetin O-dealkylation is considerably less than that of benzo[a]pyrene hydroxylation, the data indicate that in mice, the metabolism of these two substrates is under similar regulatory control. Copyright © 1975 by The American Society for Pharmacology and Experimental Therapeutics ER -