RT Journal Article SR Electronic T1 EFFECT OF 3-METHYLCHOLANTHRENE TREATMENT ON PHENACETIN O-DEALKYLATION IN SEVERAL INBRED MOUSE STRAINS JF Drug Metabolism and Disposition JO Drug Metab Dispos FD American Society for Pharmacology and Experimental Therapeutics SP 502 OP 506 VO 3 IS 6 A1 P. J. POPPERS A1 W. LEVIN A1 A. H. CONNEY YR 1975 UL http://dmd.aspetjournals.org/content/3/6/502.abstract AB An increase in the metabolism of phenacetin to N-acetyl-p-aminophenol is correlated with benzo[a]pyrene hydroxylase induction by 3-methylcholanthrene among several inbred mouse strains. While the magnitude of induction of phenacetin O-dealkylation is considerably less than that of benzo[a]pyrene hydroxylation, the data indicate that in mice, the metabolism of these two substrates is under similar regulatory control. Copyright © 1975 by The American Society for Pharmacology and Experimental Therapeutics