RT Journal Article
SR Electronic
T1 EFFECT OF 3-METHYLCHOLANTHRENE TREATMENT ON PHENACETIN O-DEALKYLATION IN SEVERAL INBRED MOUSE STRAINS
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 502
OP 506
VO 3
IS 6
A1 POPPERS, P. J.
A1 LEVIN, W.
A1 CONNEY, A. H.
YR 1975
UL http://dmd.aspetjournals.org/content/3/6/502.abstract
AB An increase in the metabolism of phenacetin to N-acetyl-p-aminophenol is correlated with benzo[a]pyrene hydroxylase induction by 3-methylcholanthrene among several inbred mouse strains. While the magnitude of induction of phenacetin O-dealkylation is considerably less than that of benzo[a]pyrene hydroxylation, the data indicate that in mice, the metabolism of these two substrates is under similar regulatory control. Copyright © 1975 by The American Society for Pharmacology and Experimental Therapeutics