RT Journal Article
SR Electronic
T1 Biotransformation of Drugs in Human Skin
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 247
OP 253
DO 10.1124/dmd.108.024794
VO 37
IS 2
A1 Craig K. Svensson
YR 2009
UL http://dmd.aspetjournals.org/content/37/2/247.abstract
AB Although it is the largest organ of the human body, skin is often not considered in discussions of drug metabolism. However, there is growing evidence that most common drug-metabolizing enzymes are expressed in the skin. Evidence for expression of cytochromes P450, flavin monooxygenases, glutathione-S-transferases, N-acetyltransferases, and sulfotransferases in human skin and skin cells are presented. Additional discussion is focused on the evidence of actual metabolism of drugs. Finally, the potential clinical implications of metabolism within the skin are discussed briefly. The American Society for Pharmacology and Experimental Therapeutics