PT  - JOURNAL ARTICLE
AU  - J A Hinson
AU  - J R Mitchell
TI  - N-Hydroxylation of phenacetin by hamster liver microsomes.
DP  - 1976 Sep 01
TA  - Drug Metabolism and Disposition
PG  - 430--435
VI  - 4
IP  - 5
4099  - http://dmd.aspetjournals.org/content/4/5/430.short
4100  - http://dmd.aspetjournals.org/content/4/5/430.full
SO  - Drug Metab Dispos1976 Sep 01; 4
AB  - Hamster liver microsomes have been shown to catalyze the N-hydroxylation of phenacetin. The reaction, which requires oxygen and NADPH, is inhibited by a carbon monoxide/oxygen atmosphere, indicating that it is catalyzed by a cytochrome P-450-dependent mixed-function oxidase. The N-hydroxyphenacetin can be further metabolized by the microsomes, and the reaction is inhibited by phenacetin.