TY - JOUR T1 - N-Hydroxylation of phenacetin by hamster liver microsomes. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 430 LP - 435 VL - 4 IS - 5 AU - J A Hinson AU - J R Mitchell Y1 - 1976/09/01 UR - http://dmd.aspetjournals.org/content/4/5/430.abstract N2 - Hamster liver microsomes have been shown to catalyze the N-hydroxylation of phenacetin. The reaction, which requires oxygen and NADPH, is inhibited by a carbon monoxide/oxygen atmosphere, indicating that it is catalyzed by a cytochrome P-450-dependent mixed-function oxidase. The N-hydroxyphenacetin can be further metabolized by the microsomes, and the reaction is inhibited by phenacetin. ER -