PT  - JOURNAL ARTICLE
AU  - Sum, C Y
AU  - Cho, A K
TI  - Properties of microsomal enzyme systems that reduce N-hydroxyphentermine.
DP  - 1976 Sep 01
TA  - Drug Metabolism and Disposition
PG  - 436--441
VI  - 4
IP  - 5
4099  - http://dmd.aspetjournals.org/content/4/5/436.short
4100  - http://dmd.aspetjournals.org/content/4/5/436.full
SO  - Drug Metab Dispos1976 Sep 01; 4
AB  - The reduction of N-hydroxyphentermine was studied in liver microsomes isolated from rat, guinea pig, and rabbit. The reduction requires a NADPH-generating system and was inhibited by oxygen and carbon monoxide. In the rat, the reduction was increased by phenobarbital pretreatment. Kinetic analysis of the reductase activity in rat liver microsomes suggests that the reduction of the hydroxylamine is mediated by at least two enzyme systems, one of which is a CO-sensitive system inducible by phenobarbital.