RT Journal Article
SR Electronic
T1 Metabolism of methoxyphenamine in man and in monkey.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 568
OP 576
VO 4
IS 6
A1 Midha, K K
A1 Cooper, J K
A1 Mcgilveray, I J
A1 Coutts, R T
A1 Dawe, R
YR 1976
UL http://dmd.aspetjournals.org/content/4/6/568.abstract
AB Metabolites of methoxyphenamine in the urine of human subjects and monkeys were separated by gas-liquid chromatography and identified by comparison of their chromatographic and mass spectrometric behavior with those of synthetic compounds. Aromatic O-demethylation, aromatic ring hydroxylation (both followed by glucuronide conjugation), and N-demethylation were shown to occur in man as well as in monkey. In man these were the principal metabolites, whereas in the monkey three additional unidentified major metabolites were formed.