RT Journal Article
SR Electronic
T1 N-Hydroxylation of pentobarbital in man.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 71
OP 74
VO 5
IS 1
A1 B K Tang
A1 T Inaba
A1 W Kalow
YR 1977
UL http://dmd.aspetjournals.org/content/5/1/71.abstract
AB After oral administration of 14C-labeled pentobarbital to healthy subjects, most ot the radioactivity was recovered in urine over a period of 6 days. Only a minute amount (approximately 1%) of unchanged pentobarbital was found in the urine. Four major metabolites were found and isolated. One was 3'-hydroxypentobarbital, which has been previously identified by Maynert. The second could be identified as N-hydroxypentobarbital on the basis of its spectral and chemical properties. The other two metabolites were not identified.