PT  - JOURNAL ARTICLE
AU  - D C Hobbs
AU  - T M Twomey
TI  - Metabolism of sudoxicam by the rat, dog, and monkey.
DP  - 1977 Jan 01
TA  - Drug Metabolism and Disposition
PG  - 75--81
VI  - 5
IP  - 1
4099  - http://dmd.aspetjournals.org/content/5/1/75.short
4100  - http://dmd.aspetjournals.org/content/5/1/75.full
SO  - Drug Metab Dispos1977 Jan 01; 5
AB  - Sudoxicam, N-(2-thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1, 1-dioxide, was prepared in radiolabeled form and administered to rats, dogs, and monkeys. Urine contained approximately 60, 25, and 49% of the label given to rats, dogs, and monkeys, respectively; the remainder was cleared via feces. In addition to some unchanged drug, urine from all species examined contained two major metabolites. These were identified from their mass spectra as the thiohydantoic acid and thiourea resulting from scission of the thiazole ring of sudoxicam.