TY - JOUR T1 - Metabolism of sudoxicam by the rat, dog, and monkey. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 75 LP - 81 VL - 5 IS - 1 AU - D C Hobbs AU - T M Twomey Y1 - 1977/01/01 UR - http://dmd.aspetjournals.org/content/5/1/75.abstract N2 - Sudoxicam, N-(2-thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1, 1-dioxide, was prepared in radiolabeled form and administered to rats, dogs, and monkeys. Urine contained approximately 60, 25, and 49% of the label given to rats, dogs, and monkeys, respectively; the remainder was cleared via feces. In addition to some unchanged drug, urine from all species examined contained two major metabolites. These were identified from their mass spectra as the thiohydantoic acid and thiourea resulting from scission of the thiazole ring of sudoxicam. ER -