PT  - JOURNAL ARTICLE
AU  - H B Hucker
AU  - A J Balletto
AU  - J Demetriades
AU  - B H Arison
AU  - A G Zacchei
TI  - Urinary metabolites of amitriptyline in the dog.
DP  - 1977 Mar 01
TA  - Drug Metabolism and Disposition
PG  - 132--142
VI  - 5
IP  - 2
4099  - http://dmd.aspetjournals.org/content/5/2/132.short
4100  - http://dmd.aspetjournals.org/content/5/2/132.full
SO  - Drug Metab Dispos1977 Mar 01; 5
AB  - Dogs excreted approximately 45% of an oral dose of 14C-amitriptyline (30 mg/kg) in the urine in 24 hr. Two new urinary metabolites of the drug were identified as dihydrodiol derivatives of amitriptyline and nortriptyline, respectively. The major metabolite in dog urine was 10-hydroxyamitriptyline, excreted mainly in conjugated form. Other metabolites were characterized as 10-hydroxynortriptyline, amitriptyline N-oxide, and nortriptyline. Together, these metabolites accounted for approximately 47% of the urinary radioactivity.