RT Journal Article
SR Electronic
T1 Postnatal development of mixed-function oxidation as measured in microsomes from the small intestine and liver of rabbits.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 17
OP 24
VO 4
IS 1
A1 J M Tredger
A1 R S Chhabra
A1 J R Fouts
YR 1976
UL http://dmd.aspetjournals.org/content/4/1/17.abstract
AB The postnatal development of aminopyrine N-demethylase, aniline 4-hydroxylase, benzpyrene hydroxylase, biphenyl 4-hydroxylase, 7-ethoxycoumarin 0-deethylase activities, NADPH-cytochrome c reductase, and cytochrome P-450 was compared in microsomes from the liver and small intestine of New Zealand white rabbits. Apart from hepatic aniline hydroxylase activity, all of the xenobiotic-metabolizing enzyme activities examined had a similar pattern of development in the liver and small intestine. In both tissues the ability to metabolize xenobiotics was generally undetectable at 2 days of age and remained relatively low for the first 20 days of life. Theresfter, a rapid 2- to 5-fold increase in all the enzyme activity studied was noted, and adult values were reached or exceeded by 30 days of age. Subsequent development of xenobiotic-metabolizing enzyme activities in the small intestine, but not in the liver, exhibited a transient fall at 50 days of age before adult activities were attained after 75 days of age. The developmental pattern of cytochrome P-450 in the small intestine closely resembled that of the xenobiotic-metabolizing enzyme activities, but in the liver this correlation was less exact.