RT Journal Article SR Electronic T1 Pharmacokinetics of intravenously injected chloramphenicol in baby pigs. JF Drug Metabolism and Disposition JO Drug Metab Dispos FD American Society for Pharmacology and Experimental Therapeutics SP 253 OP 258 VO 5 IS 3 A1 V R Rao A1 R Clarenburg YR 1977 UL http://dmd.aspetjournals.org/content/5/3/253.abstract AB A sensitive fluorometric assay procedure for chloramphenicol and its metabolites was used to measure distribution in tissues and elimination of the drug after injection of 22 mg/kg iv in baby pigs. Disappearance of chloramphenicol from plasma was biphasic; an initial component was rapid (half-life about 9 min) and a second component had a half-life of 55 min. The total chloramphenicol levels in tissues and body fluids had half-life periods of 1-1.5 hr and dropped below limits of detectability within 9 hr after injection. About 80% of the injected dose was recovered from urine collected over the first 6 hr, and none thereafter. Fecal elimination, if occurring, was negligible.