%0 Journal Article %A A J Ryan %A J R Bend %T The metabolism of styrene oxide in the isolated perfused rat liver. Identification and quantitation of major metabolites. %D 1977 %J Drug Metabolism and Disposition %P 363-367 %V 5 %N 4 %X Isolated perfused rat livers rapidly metabolized 14C-styrene oxide. A large proportion of the administered radioactivity was excreted in the bile as a single compound that was identified as S-(1-phenyl-2-hydroxyethyl)glutathione by comparison with an authentic synthetic standard. The circulating perfusate was found to contain approximately equal amounts of styrene glycol, mandelic acid, and the glutathione derivative. %U https://dmd.aspetjournals.org/content/dmd/5/4/363.full.pdf