RT Journal Article
SR Electronic
T1 Identification of the metabolites of trichlorocarbanilide in the rat.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 38
OP 44
VO 6
IS 1
A1 J T Warren
A1 R Allen
A1 D E Carter
YR 1978
UL http://dmd.aspetjournals.org/content/6/1/38.abstract
AB The metabolism and excretion of 14C-labeled 3,4,4'-trichlorodiphenylurea has been studied in the rat after oral and iv administration. More than 80% of the administered radioactivity was excreted in the feces and urine over 5 days. Five isolated metabolites were characterized by mass spectrometry and by comparative thin-layer chromatography with synthesized compounds. Metabolites found include 2'-hydroxy-, 3'-hydroxy-, 6-hydroxy-, 2',6-dihydroxy- and 3',6-dihydroxy-3,4,4'-trichlorodiphenylurea.