TY - JOUR T1 - Formation of sulfone metabolites from chlorpromazine and perazine in man. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 114 LP - 119 VL - 6 IS - 2 AU - U Breyer-Pfaff AU - H Kreft AU - H Rassner AU - A Prox Y1 - 1978/03/01 UR - http://dmd.aspetjournals.org/content/6/2/114.abstract N2 - Didesmethylchlorpromazine sulfone [gamma-(2-chlorophenothiazinyl-10)-propylamine sulfone] has been isolated from the urine of a patient under continuous chlorpromazine therapy and identified by mass spectrometry. The same compound was present in organs of rats after injection of the corresponding sulfide. The Cl-free analogue, gamma-(phenothiazinyl-10)-propylamine sulfone, was excreted by patients receiving perazine and by a volunteer after ingestion of the primary amine sulfoxide. ER -