RT Journal Article
SR Electronic
T1 Formation of sulfone metabolites from chlorpromazine and perazine in man.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 114
OP 119
VO 6
IS 2
A1 U Breyer-Pfaff
A1 H Kreft
A1 H Rassner
A1 A Prox
YR 1978
UL http://dmd.aspetjournals.org/content/6/2/114.abstract
AB Didesmethylchlorpromazine sulfone [gamma-(2-chlorophenothiazinyl-10)-propylamine sulfone] has been isolated from the urine of a patient under continuous chlorpromazine therapy and identified by mass spectrometry. The same compound was present in organs of rats after injection of the corresponding sulfide. The Cl-free analogue, gamma-(phenothiazinyl-10)-propylamine sulfone, was excreted by patients receiving perazine and by a volunteer after ingestion of the primary amine sulfoxide.