RT Journal Article
SR Electronic
T1 Metabolism and tissue distribution of mono-2-ethylhexyl phthalate in the rat.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 146
OP 149
VO 6
IS 2
A1 I Chu
A1 D C Villeneuve
A1 V Secours
A1 C Franklin
A1 G Rock
A1 A Viau
YR 1978
UL http://dmd.aspetjournals.org/content/6/2/146.abstract
AB The absorption, distribution and metabolic excretion of mono-2-ethylhexyl [7-14C]phthalate (MEHP) were studied in the rat. This compound was readily absorbed from the gastrointestinal tract. Radioactivity following intravenous administration of 14C-MEHP was rapidly distributed in all tissues, with the highest levels occurring in the liver, kidney, and urinary bladder. Excretion of radioactivity was rapid and approximately 80% of the dose was eliminated 24 hr after oral administration, 72% in the urine and 8% in feces. MEHP was extensively metabolized after oral administration, and the major urinary metabolites were identified as an alcohol, a ketone, and an acid resulting from the side-chain oxidation of MEHP. A trace of o-phthalic acid was also identified.