PT  - JOURNAL ARTICLE
AU  - A Karim
AU  - C Kook
AU  - R L Novotney
AU  - J Zagarella
AU  - J Campion
TI  - Pharmacokinetics and steady-state myocardial uptake of disopyramide in the dog.
DP  - 1978 May 01
TA  - Drug Metabolism and Disposition
PG  - 338--345
VI  - 6
IP  - 3
4099  - http://dmd.aspetjournals.org/content/6/3/338.short
4100  - http://dmd.aspetjournals.org/content/6/3/338.full
SO  - Drug Metab Dispos1978 May 01; 6
AB  - The pharmacokinetics and steady-state myocardial uptake of the antiarrhythmic drug disopyramide (DP) were determined in dogs after oral or intravenous administration of [14C]disopyramide phosphate. DP was absorbed rapidly and its absolute oral bioavailability was about 70%. Significant dose-dependent kinetics were not apparent after 7.5- to 30-mg/kg po doses. Plasma half-lives of DP were about 2.9 and 1.2 hr after the po and iv doses, respectively. DP and its N-dealkylated metabolites were largely excreted in the urine and their composition was qualitatively similar after the po and iv doses. Marked differences in the protein binding of DP in human and dog plasma were found. In the papillary muscle, ventricular septum, and ventricles of one dog, the steady-state concentrations of DP and its less active mono-N-dealkylated metabolite were about twice those in plasma, whereas in the atria and tricuspid and mitral valves they were similar to those in plasma.