TY - JOUR T1 - Microsomal metabolism of cyclohexene. Hydroxylation in the allylic position. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 375 LP - 378 VL - 6 IS - 4 AU - K C Leibman AU - E Ortiz Y1 - 1978/07/01 UR - http://dmd.aspetjournals.org/content/6/4/375.abstract N2 - Hydroxylation of cyclohexene at the allylic position has been shown to occur in hepatic microsomes and 9000 g supernatant fractions of rats and rabbits. The formation of the product, 2-cyclohexen-1-ol, requires the presence of a NADPH-generating system, is inhibited by CO, metyrapone, and SKF 525-A, and is induced by pretreatment with phenobarbital. A small amount of 2-cyclohexen-1-one is also formed in preparations from phenobarbital-pretreated rats. No 2-cyclohexen-1-ol could be detected in the beta-glucuronidase-hydrolyzed urine of rats given cyclohexene orally; however, these rats excreted a small quantity of 2-cyclohexen-1-one. ER -