PT  - JOURNAL ARTICLE
AU  - K C Leibman
AU  - E Ortiz
TI  - Microsomal metabolism of cyclohexene. Hydroxylation in the allylic position.
DP  - 1978 Jul 01
TA  - Drug Metabolism and Disposition
PG  - 375--378
VI  - 6
IP  - 4
4099  - http://dmd.aspetjournals.org/content/6/4/375.short
4100  - http://dmd.aspetjournals.org/content/6/4/375.full
SO  - Drug Metab Dispos1978 Jul 01; 6
AB  - Hydroxylation of cyclohexene at the allylic position has been shown to occur in hepatic microsomes and 9000 g supernatant fractions of rats and rabbits. The formation of the product, 2-cyclohexen-1-ol, requires the presence of a NADPH-generating system, is inhibited by CO, metyrapone, and SKF 525-A, and is induced by pretreatment with phenobarbital. A small amount of 2-cyclohexen-1-one is also formed in preparations from phenobarbital-pretreated rats. No 2-cyclohexen-1-ol could be detected in the beta-glucuronidase-hydrolyzed urine of rats given cyclohexene orally; however, these rats excreted a small quantity of 2-cyclohexen-1-one.