TY - JOUR T1 - Synthesis and characterization of glucuronides of 5'-hydroxy-delta9-tetrahydrocannabinol and 11-hydroxy-delta9-tetrahydrocannabinol. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 389 LP - 395 VL - 6 IS - 4 AU - S Pallante AU - M A Lyle AU - C Fenselau Y1 - 1978/07/01 UR - http://dmd.aspetjournals.org/content/6/4/389.abstract N2 - Glucuronides of two metabolites of delta9-tetrahydrocannabinol, 11-hydroxy-delta9-THC and 5'-hydroxy-delta9-THC, have been synthesized and characterized. Two isomeric monoglucuronides were isolated from the incubation of each metabolite with UDP-glucuronyltransferase immobilized on beaded Sepharose. The structures of these conjugates were assigned primarily on the basis of combined gas chromatography-mass spectrometry. ER -