TY - JOUR T1 - Metabolism of levorotary 4,5-dihydrodiazepam in the rat. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 213 LP - 217 VL - 6 IS - 3 AU - L Otvös AU - Z Tegyey AU - L Vereczkey AU - M Ledniczky AU - J Tamás AU - E Pálosi AU - L Szporny Y1 - 1978/05/01 UR - http://dmd.aspetjournals.org/content/6/3/213.abstract N2 - The metabolism of (-)-4,5-dihydrodiazepam (7-chloro-1,3,4,5-tetrahydro-1-methyl-5-phenyl-2H-1,4-benzo[2-14C]diazepin-2-one) (I) was investigated in rats. Metabolites from urine and bile extracts purified by thin-layer chromatography were identified by mass spectrometry. Diazepam and its main metabolites were found among the biotransformation products of I. Based on these findings, the most important identified metabolic route of the compound studied appears to be the formation of an unsaturated bond between the N4 and C5 atoms, and further transformation of the diazepam formed. ER -