@article {Walle481, author = {T Walle and E C Conradi and U K Walle and T E Gaffney}, title = {O-methylated catechol-like metabolites of propranolol in man.}, volume = {6}, number = {4}, pages = {481--487}, year = {1978}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Two isomeric methoxyhydroxy metabolites of propranolol have been identified in man during chronic antihypertensive propranolol therapy. The identification was based on the mass-spectral fragmentation pattern of their trifluoroacetylated derivatives. Both isomers were detected in urine as well as in plasma, mainly as glucuronic acid and/or sulfate conjugates. The amounts of these metabolites excreted in urine were linearly related (r = 0.84) to the oral propranolol dose, 10--320 mg per day. Plasma concentrations at the 320-mg daily dose ranged from 20 to 112 ng/ml. Similar isomeric methoxyhydroxy metabolites of propranolol containing a glycol or a lactic acid side-chain were also identified.}, issn = {0090-9556}, URL = {https://dmd.aspetjournals.org/content/6/4/481}, eprint = {https://dmd.aspetjournals.org/content/6/4/481.full.pdf}, journal = {Drug Metabolism and Disposition} }