RT Journal Article SR Electronic T1 O-methylated catechol-like metabolites of propranolol in man. JF Drug Metabolism and Disposition JO Drug Metab Dispos FD American Society for Pharmacology and Experimental Therapeutics SP 481 OP 487 VO 6 IS 4 A1 T Walle A1 E C Conradi A1 U K Walle A1 T E Gaffney YR 1978 UL http://dmd.aspetjournals.org/content/6/4/481.abstract AB Two isomeric methoxyhydroxy metabolites of propranolol have been identified in man during chronic antihypertensive propranolol therapy. The identification was based on the mass-spectral fragmentation pattern of their trifluoroacetylated derivatives. Both isomers were detected in urine as well as in plasma, mainly as glucuronic acid and/or sulfate conjugates. The amounts of these metabolites excreted in urine were linearly related (r = 0.84) to the oral propranolol dose, 10--320 mg per day. Plasma concentrations at the 320-mg daily dose ranged from 20 to 112 ng/ml. Similar isomeric methoxyhydroxy metabolites of propranolol containing a glycol or a lactic acid side-chain were also identified.