RT Journal Article
SR Electronic
T1 Studies on disposition and metabolism of tolmetin, a new anti-inflammatory agent, in rats and mice. II. Urinary metabolites.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 20
OP 23
VO 7
IS 1
A1 M Hashimoto
A1 H Miyazaki
A1 K Nambu
A1 T Fujii
A1 S Arakawa
A1 K Yoshida
A1 Y Utsui
YR 1979
UL http://dmd.aspetjournals.org/content/7/1/20.abstract
AB A new urinary metabolite of tolmetin was found in rat urine and identified as the hydroxymethyl metabolite (tolmetin-OH), an intermediate in the formation of the known carboxy metabolite (tolmetin-COOH). In rats of two strains, the following percentages of the urinary reactivity of [14Ia1tolmetin were found in 24 hr: unchanged tolmetin-COOH (58--60%), tolmetin-OH (18--24 %), and its conjugate 6--14%. Mouse urine contained the unchanged drug (about 20%), its conjugate and tolmetin-COOH (60%). Similarly to mouse urine, human urine contained negligible amounts of tolmetin-OH.