@article {Stohs49, author = {S J Stohs and L A Reinke and J M Hassing and H Rosenberg}, title = {Benzo[a]pyrene metabolism by hepatic and extrahepatic tissues in streptozotocin-diabetic rats.}, volume = {7}, number = {1}, pages = {49--51}, year = {1979}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The metabolism of benzo[a]pyrene (BP) by microsomes from hepatic and extrahepatic tissues of female diabetic rats was investigated. Diabetes was produced by the administration of streptozotocin, 60 mg/kg iv, and BP metabolism was studied 7 or 10 days later. BP metabolism was increased in hepatic microsomes by 75\% in diabetic animals. Cytochrome P-450 levels were similarly increased. BP mono-oxygenase activity was tripled in intestinal microsomes of diabetic rats, and returned to control values on insulin treatment. The BP mono-oxygenase activity in lung microsomes from diabetic rats decreased by 40\%, and was increased to control levels after insulin treatment. No significant changes in BP metabolism were observed in the kidney and adrenal tissues of diabetic animals.}, issn = {0090-9556}, URL = {https://dmd.aspetjournals.org/content/7/1/49}, eprint = {https://dmd.aspetjournals.org/content/7/1/49.full.pdf}, journal = {Drug Metabolism and Disposition} }