RT Journal Article
SR Electronic
T1 Biotransformation of mazindol. II. Absorption and excretion in the dog and man.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 129
OP 131
VO 7
IS 3
A1 H A Dugger
A1 J G Heider
YR 1979
UL http://dmd.aspetjournals.org/content/7/3/129.abstract
AB On administration of tritium-labeled mazindol (l) to man and the dog, absorption was slow but complete. Excretion was slow in both dog and man, but the dog did excrete the drug and/or metabolites faster than man. Blood levels of l in man after a single oral dose of a 2-mg tablet reached a peak value of 2.5 ng/ml, which remained essentially unchanged for at least 6 hr. After multiple doses of a 2-mg tablet t.i.d. for 4 days to subjects who had been receiving nonlabeled l, 2 mg t.i.d. for 6 months, the blood level reached a maximum concentration of 10.8 ng/ml, measured 2 hr after the last dose on day 4. This value is somewhat higher than predicted by the single-dose data, indicating that in man, mazindol does not induce its own metabolism.