TY - JOUR T1 - Isolation and identification of urinary metabolites of oxycodone in rabbits. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 162 LP - 165 VL - 7 IS - 3 AU - T Ishida AU - K Oguri AU - H Yoshimura Y1 - 1979/05/01 UR - http://dmd.aspetjournals.org/content/7/3/162.abstract N2 - Metabolism of oxycodone was studied in the rabbit and found to proceed through five metabolic pathways: O-demethylation, N-demethylation, N-oxidation, 6-keto reduction, and glucuronidation. Six urinary metabolites were isolated and identified in the unconjugated form: 14-hydroxydihydromorphinone, 14-hydroxydihydrocodeine, 14-hydroxydihydrocodeinone N-oxide (oxycodone N-oxide), 14-hydroxydihydroisocodeine, 14-hydroxydihydrocodeine N-oxide, and noroxycodone, together with unchanged oxycodone. Identification was made by means of various chromatographic and spectral comparisons with authentic samples. Oxycodone, 14-hydroxydihydromorphinone, 14-hydroxydihydrocodeine, 14-hydroxydihydroisocodeine, and noroxycodone were also identified as aglycons of conjugated metabolites. ER -