PT  - JOURNAL ARTICLE
AU  - M N Cayen
AU  - E S Ferdinandi
AU  - E Greselin
TI  - Distribution and excretion of furobufen in rats and dogs.
DP  - 1981 Mar 01
TA  - Drug Metabolism and Disposition
PG  - 125--128
VI  - 9
IP  - 2
4099  - http://dmd.aspetjournals.org/content/9/2/125.short
4100  - http://dmd.aspetjournals.org/content/9/2/125.full
SO  - Drug Metab Dispos1981 Mar 01; 9
AB  - Groups of male rats and dogs were given single doses of 50 mg of 14C-furobufen per kg orally or intravenously. In rats, tissue radioactivity levels were generally lower than that of serum. Radioactivity accumulated in and was retained by white adipose tissue. The radioactivity in fat was due to a conjugate of dibenzofuranacetic acid, the major metabolite of furobufen. Approximately one-half of the dose was excreted each in the urine and feces of rats after oral and intravenous administration of 14C-furobufen. A similar excretion pattern was observed in dogs after an oral dose.