@article {Acara75, author = {M Acara and T Gessner and H Greizerstein and R Trudnowski}, title = {Renal N-oxidation of meperidine by the perfused kidney of the rat.}, volume = {9}, number = {2}, pages = {75--79}, year = {1981}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Isolated perfused kidneys of rats were used to determined renal metabolism of meperidine and its relation to meperidine excretion. Starting perfusate concentrations of meperidine were 18.4 and 190 micrograms/ml, and resulted in respective nonsaturation and saturation kinetics for removal of meperidine. Disposition of 14C-meperidine was followed and supplemented with measurements of meperidine by gas chromatography. A major renal metabolite was shown to facilitate the renal excretion of meperidine. This metabolite was identified by gas chromatography/mass spectrometry as the N-oxide of meperidine.}, issn = {0090-9556}, URL = {https://dmd.aspetjournals.org/content/9/2/75}, eprint = {https://dmd.aspetjournals.org/content}, journal = {Drug Metabolism and Disposition} }