TY - JOUR T1 - The biodistribution and metabolic fate of inhaled 11C-octanal in the rat after acute exposure. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 331 LP - 333 VL - 9 IS - 4 AU - R S Kutzman AU - G J Meyer AU - A P Wolf AU - T Akasaka Y1 - 1981/07/01 UR - http://dmd.aspetjournals.org/content/9/4/331.abstract N2 - Rats were nose exposed to an atmosphere containing 11.4 ppm of 11C-octanal for 2 min. Inhaled octanal was absorbed from the lungs in a biphasic manner and the greatest concentration of octanal occurred in most tissues at 5 min. Tissue activities calculated on the basis of the administered dose and on the radiolabel retained until the animal was killed indicated a redistribution of the radiolabel as metabolic products after 20 min. The labeled carbon was eliminated in a biphasic manner as 11CO2, which accounted for essentially all of the activity lost by the exposed rats. ER -