PT - JOURNAL ARTICLE AU - D P Benziger AU - A K Fritz AU - S D Clemans AU - J Edelson TI - Metabolism of arildone, an antiviral agent, in laboratory animals. DP - 1981 Sep 01 TA - Drug Metabolism and Disposition PG - 424--427 VI - 9 IP - 5 4099 - http://dmd.aspetjournals.org/content/9/5/424.short 4100 - http://dmd.aspetjournals.org/content/9/5/424.full SO - Drug Metab Dispos1981 Sep 01; 9 AB - After arildone administration, four compounds were identified in the excreta of laboratory animals: unchanged drug, arildone; the O-desmethyl metabolite, 4-[6-(2-chloro-4-hydroxy)phenoxy]hexyl-3,5-heptanedione; the sulfate ester of 2-chloro-4-methoxyphenol; and a labile conjugate of chlorohydroquinone, tentatively characterized as the sulfate ester. The concentrations of each of these were determined in the urine and/or plasma of rats, dogs, and mice after administration of 14C-arildone.