PT - JOURNAL ARTICLE AU - H Yamaguchi AU - J Kubo AU - K Sekine AU - T Naruchi AU - Y Hashimoto AU - R Kato TI - Metabolites of feprazone in man. DP - 1979 Sep 01 TA - Drug Metabolism and Disposition PG - 340--344 VI - 7 IP - 5 4099 - http://dmd.aspetjournals.org/content/7/5/340.short 4100 - http://dmd.aspetjournals.org/content/7/5/340.full SO - Drug Metab Dispos1979 Sep 01; 7 AB - Two male volunteers received 400 mg of nonlabeled feprazone, 1,2-diphenyl-3,5-dioxo-4-(3'-methyl-but-2'-enyl)pyrazolidine. Metabolites were extracted and isolated by chromatography on silica gel. Isolated metabolites were unchanged drug, E-1,2-diphenyl-3,5-dioxo-4-(3'-hydroxymethyl-but-2'-enyl)pyrazolidine, and feprazone (C4)-beta-glucuronide. Feprazone (C4)-beta-glucuronide was the main metabolite and it belongs to a novel type of conjugate, (C)-beta-glucuronide.