PT - JOURNAL ARTICLE AU - B D Andresen AU - F T Davis TI - Metabolism of acebutolol-d6 in the rat correlates with the identification of a new metabolite in human urine. DP - 1979 Nov 01 TA - Drug Metabolism and Disposition PG - 360--365 VI - 7 IP - 6 4099 - http://dmd.aspetjournals.org/content/7/6/360.short 4100 - http://dmd.aspetjournals.org/content/7/6/360.full SO - Drug Metab Dispos1979 Nov 01; 7 AB - The metabolism and excretion of acebutolol-d6, [1-(2-acetyl-4-n-butyramido-phenoxy)-2-hydroxy-3--[2H6]isopropylaminopropane] has been studied in the rat. Metabolites were characterized by thin-layer and gas chromatography, mass spectrometry, and the direct comparisons of metabolites to synthetic standards. Approximately 60% of the parent drug was excreted unchanged. Two major metabolites, an acetamide and an aniline, were identified in urine samples at relative concentrations of approximately 10% and 30%, respectively. The aniline analog of acebutolol was also identified in human urine.