PT - JOURNAL ARTICLE AU - J D Osterloh AU - A Karakaya AU - D E Carter TI - Isolation and identification of the polar metabolites of chlorpheniramine in the dog. DP - 1980 Jan 01 TA - Drug Metabolism and Disposition PG - 12--15 VI - 8 IP - 1 4099 - http://dmd.aspetjournals.org/content/8/1/12.short 4100 - http://dmd.aspetjournals.org/content/8/1/12.full SO - Drug Metab Dispos1980 Jan 01; 8 AB - The metabolites of chlorpheniramine were isolated from dog urine. After daily repeated dosing with chlorpheniramine, [methylene-14C]chlorpheniramine maleate was given as a tracer and urine was collected until less than 1% of the labeled dose was excreted daily. An average of 54% of the oral radioactive dose was recovered in the urine. In addition to the N-demethylated metabolites, one very polar metabolite accounting for about 18% and two less polar metabolites accounting for a total of about 30% of the total urine radioactivity were isolated. Hydrolysis studies of the most polar metabolite indicated that it was a conjugate, though not a glucuronide or sulfate. The metabolite identified after hydrolysis was 3-(p-chlorobenzyl)-3-(2-pyridyl)propionic acid. One of the two less polar metabolites was identified as the corresponding alcohol. The least abundant metabolite could not be identified.