PT  - JOURNAL ARTICLE
AU  - W R McConnell
AU  - S M El Dareer
AU  - D L Hill
TI  - Metabolism and disposition of erythro-9-(2-hydroxy-3-nonyl)[14C]adenine in the rhesus monkey.
DP  - 1980 Jan 01
TA  - Drug Metabolism and Disposition
PG  - 5--7
VI  - 8
IP  - 1
4099  - http://dmd.aspetjournals.org/content/8/1/5.short
4100  - http://dmd.aspetjournals.org/content/8/1/5.full
SO  - Drug Metab Dispos1980 Jan 01; 8
AB  - erythro-9-(2-Hydroxy-3-nonyl)[14C]adenine was extensively metabolized by monkeys. Following iv administration of 5 mg/kg, serum levels of total radioactivity increased to a maximum between 15 and 30 min, then dropped rapidly. Thin-layer chromatography of extracts of liver, kidney, and urine revealed four metabolites. Of the radioactivity administered, urinary excretion accounted for 70% within 6 hr and 90% within 1 week. In serum, the concentration of intact drug declined rapidly; in urine, it constituted less than 0.3% of the total radioactivity.