TY - JOUR T1 - Identification of a glutathione conjugate of cambendazole formed in the presence of liver microsomes. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 131 LP - 136 DO - 10.1124/dmd.8.3.131 VL - 8 IS - 3 AU - D E Wolf AU - J A VandenHeuvel AU - T R Tyler AU - R W Walker AU - F R Koniuszy AU - V Gruber AU - B H Arison AU - A Rosegay AU - T A Jacob AU - F J Wolf Y1 - 1980/05/01 UR - http://dmd.aspetjournals.org/content/8/3/131.abstract N2 - The incubation of multiply labeled (2H, 3H, 13C, 14C) cambendazole and glutathione with hepatic microsomes from phenobarbital-dosed hamsters results in the formation of polar metabolites. The major metabolite has been characterized by a variety of isotopic, spectrometric, chromatographic, and degradative/synthetic techniques as a glutathione conjugate of cambendazole in which substitution is on the 4-position of the benzimidazole nucleus. The same metabolite is produced by hepatic microsomes from the rat. ER -