%0 Journal Article %A M Dean %A L O'Donnell %A S Penglis %A B Stock %T Antipyrine pharmacokinetics in the pregnant rat. %D 1980 %J Drug Metabolism and Disposition %P 265-267 %V 8 %N 4 %X Pronounced differences in pharmacokinetic parameters of antipyrine have been found in the 20-day pregnant hooded Wistar rat when compared with nonpregnant controls. Total body clearance falls significantly from 5.93 to 3.5 ml/min/kg in the pregnant rat whereas no significant increase in antipyrine volume of distribution occurs. These changes result in an increase in antipyrine half-life from 109 to 223 min in the pregnant rat. This study demonstrates that reduced hepatic mono-oxygenase capacity exists in the pregnant rat and that this can markedly affect drug clearance in there animals. %U https://dmd.aspetjournals.org/content/dmd/8/4/265.full.pdf