PT  - JOURNAL ARTICLE
AU  - M Dean
AU  - L O'Donnell
AU  - S Penglis
AU  - B Stock
TI  - Antipyrine pharmacokinetics in the pregnant rat.
DP  - 1980 Jul 01
TA  - Drug Metabolism and Disposition
PG  - 265--267
VI  - 8
IP  - 4
4099  - http://dmd.aspetjournals.org/content/8/4/265.short
4100  - http://dmd.aspetjournals.org/content/8/4/265.full
SO  - Drug Metab Dispos1980 Jul 01; 8
AB  - Pronounced differences in pharmacokinetic parameters of antipyrine have been found in the 20-day pregnant hooded Wistar rat when compared with nonpregnant controls. Total body clearance falls significantly from 5.93 to 3.5 ml/min/kg in the pregnant rat whereas no significant increase in antipyrine volume of distribution occurs. These changes result in an increase in antipyrine half-life from 109 to 223 min in the pregnant rat. This study demonstrates that reduced hepatic mono-oxygenase capacity exists in the pregnant rat and that this can markedly affect drug clearance in there animals.