PT  - JOURNAL ARTICLE
AU  - Magnus Ingelman-Sundberg
AU  - Xiao-Bo Zhong
AU  - Oliver Hankinson
AU  - Sudheer Beedanagari
AU  - Ai-Ming Yu
AU  - Lai Peng
AU  - Yoichi Osawa
TI  - Potential Role of Epigenetic Mechanisms in the Regulation of Drug Metabolism and Transport
AID  - 10.1124/dmd.113.053157
DP  - 2013 Oct 01
TA  - Drug Metabolism and Disposition
PG  - 1725--1731
VI  - 41
IP  - 10
4099  - http://dmd.aspetjournals.org/content/41/10/1725.short
4100  - http://dmd.aspetjournals.org/content/41/10/1725.full
SO  - Drug Metab Dispos2013 Oct 01; 41
AB  - This is a report of a symposium on the potential role of epigenetic mechanisms in the control of drug disposition sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 2013 meeting in Boston, MA, April 21, 2013. Epigenetics is a rapidly evolving area, and recent studies have revealed that expression of drug-metabolizing enzymes and transporters is regulated by epigenetic factors, including histone modification, DNA methylation, and noncoding RNAs. The symposium speakers provided an overview of genetic and epigenetic mechanisms underlying variable drug metabolism and drug response, as well as the implications for personalized medicine. Considerable insight into the epigenetic mechanisms in differential regulation of the dioxin-inducible drug and carcinogen-metabolizing enzymes CYP1A1 and 1B1 was provided. The role of noncoding microRNAs in the control of drug metabolism and disposition through targeting of cytochrome P450 (P450) enzymes and ATP-binding cassette membrane transporters was discussed. In addition, potential effects of xenobiotics on chromatin interactions and epigenomics, as well as the possible role of long noncoding RNAs in regulation of P450s during liver maturation were presented.