TY - JOUR T1 - Transcriptional Regulation of CYP2D6 Expression JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 42 LP - 48 DO - 10.1124/dmd.116.072249 VL - 45 IS - 1 AU - Xian Pan AU - Miaoran Ning AU - Hyunyoung Jeong Y1 - 2017/01/01 UR - http://dmd.aspetjournals.org/content/45/1/42.abstract N2 - CYP2D6-mediated drug metabolism exhibits large interindividual variability. Although genetic variations in the CYP2D6 gene are well known contributors to the variability, the sources of CYP2D6 variability in individuals of the same genotype remain unexplained. Accumulating data indicate that transcriptional regulation of CYP2D6 may account for part of CYP2D6 variability. Yet, our understanding of factors governing transcriptional regulation of CYP2D6 is limited. Recently, mechanistic studies of increased CYP2D6-mediated drug metabolism in pregnancy revealed two transcription factors, small heterodimer partner (SHP) and Krüppel-like factor 9, as a transcriptional repressor and an activator, respectively, of CYP2D6. Chemicals that increase SHP expression (e.g., retinoids and activators of farnesoid X receptor) were shown to downregulate CYP2D6 expression in the humanized mice as well as in human hepatocytes. This review summarizes the series of studies on the transcriptional regulation of CYP2D6 expression, potentially providing a basis to better understand the large interindividual variability in CYP2D6-mediated drug metabolism. ER -